Bones' 16 Biggest Moments

Angela's real name is revealed (Season 10, Episode 21)

Never, ever, in a million years could we have predicted Angela's moniker: Pookie Noodlin!

Booth has a brain tumor (Season 4, Episode 25)

The G-man's major medical crisis not only results in hallucinations of Family Guy's Stewie during an interrogation, but also sends him into a four-day coma post-surgery. Considering the gravity of his situation, it's no wonder Booth has a strange alt reality dream, in which he and Brennan are married and expecting.

Booth and Brennan share a mistletoe kiss (Season 3, Episode 9)

It might not have been their first kiss, as viewers would come to find out in Episode 100, but it was the first one that had 'shippers hitting the rewind button over and over and over.

Booth and Brennan get married (Season 9, Episode 6)

The couple finally "caught each other" in a beautiful ceremony, during which Brennan — in a wonderfully nostalgic throwback — reads the letter she wrote to Booth while buried alive as her vows.

Booth's "I'm the gambler" speech to Brennan (Season 5, Episode 16)

For the show's 100th episode, Booth takes a gamble and puts his heart on the line during a swoon-worthy confession to Brennan: "I'm the gambler. I believe in giving this a chance. Look, I want to give this a shot. ... When you talk to older couples who, you know, have been in love for 30 or 40 or 50 years, alright, it's always the guy who says, 'I knew.' I knew. Right from the beginning. ... I'm that guy. Bones, I'm that guy. I know."

How she rejected him, we'll never understand.

Vincent Nigel-Murray's death leads Booth and Brennan to have sex (Season 6, Episode 22)

Shaken by the demise of the squintern, Brennan climbs into Booth's bed, looking for comfort. But the pair did more than just hold each other. With that monumental development, the partners' relationship — and the show — would never be the same.

Brennan and Hodgins are buried alive (Season 2, Episode 9)

In the intense and emotional hour, the Gravedigger traps Brennan and Hodgins underground in a car, leaving them with precious little time, resources and air. During the harrowing experience, the two MacGyver a way to make more oxygen and rig the airbag into an explosive. Brennan also performs surgery on Hodgins, who confesses that he's "stupid in love" with Angela. The docs live, of course, and Hodgins even scores a kiss from Angela.

The remains of Brennan's mother are found (Season 1, Episode 22)

The ensuing investigation unearths a wealth of information about Brennan's family history, leads to the introduction of her brother Russ and sets the stage for dad Max's eventual homecoming.

Cam's secret boyfriend is... Arastoo! (Season 8, Episode 7)

The über professional head of the Jeffersonian surprised everyone when she fell for a squintern.

Angela and Hodgins get married in a jail cell (Season 5, Episode 20)

While locked up, the exes realize they never should have broken up and decide to get hitched behind bars. #cellmates

Hodgins is paralyzed (Season 11, Episode 10)

After a body blows up and knocks him out, Hodgins is left with no feeling in his legs. He eventually overcomes the anger and denial stages of his paralysis and settles into a place of acceptance.

Sweets dies (Season 10, Episode 1)

Oh, sweet Lance. The FBI psychologist (played by seven-year Bones vet John Francis Daley) left his colleagues and pals with these last words: "The world is a lot better than you think it is."

Zack is Gormogon's apprentice (Season 3, Episode 15)

The Jeffersonian team's discovery that one of their own is working with the killer proves that it always hurts most when it hits close to home.

Brennan tells Booth she's pregnant with his child (Season 6, Episode 23)

The expression on Booth's face pretty much says it all.

The Jeffersonian lab is blown up (Season 12, Episode 11)

Well, that's one very effective way to get rid of your largest standing set.

Brennan gives birth (Season 7, Episode 7)

The arrival of Brennan and Booth's first child is made all the more memorable thanks to not one, but two unexpected locations: Dr. B goes into labor during a prison visit and then gives birth in the barn of an inn.