Grey's Anatomy: Who Should Play Owen's Sis?

Alyson Hannigan
Though she just signed on as host of Penn & Teller: Fool Us, Buffy's erstwhile Willow and her new colleagues should be able to work the magic necessary for her to do two series at once.

Felicia Day
Not only does the casualty of Dr. Horrible's Sing-Along Blog have the chops to hold her own among Grey's heavyweights, she also has a voice that practically demands another musical episode.

Mallory Jansen
Since it appears that ABC is pulling the plug on Galavant, maybe the network will d'dew us a favor and let Madalena's enchanting portrayer be the one to bring Megan back to life.

Sarah Brown
On soap after soap, the Daytime Emmy winner proved that she could throw sparks with just about anybody. So she'd have no trouble turning up the heat with Megan's old flame, Nathan.

Rachel Nichols
Fresh off her Chicago Fire run (where she "burned" poor Severide a bit), the Continuum/Alias alum seems overdue to heat things up in Shondaland.

Lauren Ambrose
Hot off her stint as The X-Files' Einstein, the Six Feet Under alum would be believable both as a passionate doctor and someone whose loss could make enemies of the men who loved her.

Alicia Witt
Considering the impression that she made in a single episode of The Walking Dead, Grey's would have to be as brain-dead as a zombie not to want her scrubbing in at Grey Sloan.